An explosion near a mosque in a Shia area of the Pakistani city of Karachi has killed at least 45 people and injured dozens more, police say.

Cardinal Keith O'Brien admits his sexual conduct has at times "fallen beneath the standards expected of me" after the claims that prompted his resignation.

Arsenal say owner Stan Kroenke "has no intention" of selling his shares following reports of interest from the Middle East.

An MP is calling on police to boost its probe into child sex grooming allegations in Greater Manchester.

Delegates from 178 countries will review the convention on international trade in endangered species (CITES) amidst an unprecedented extinction crisis.

David Cameron insists there will be no "lurch to the right" by the Conservatives in the wake of the party's defeat in the Eastleigh by-election.

Former President Hosni Mubarak will face retrial on 13 April over the deaths of protesters, Egypt's appeals court has decided, state media say.

QPR boss Harry Redknapp angrily denies a newspaper report that a training break in Dubai descended into a "stag party".