After decades of efforts to block the tumor-driving RAS protein, the FDA approved daraxonrasib after unprecedented survival gains in metastatic pancreatic cancer; treatment costs about NIS 90,000 a month, raising access concerns

Japanese artist famed for her polka dots, pumpkins and immersive mirrored rooms dies in Tokyo after a career spanning eight decades; her studio said she painted until her final days

Royals return to Britain with Archie and Lilibet aboard a private jet, reviving scrutiny of the Sussexes’ environmental messaging after years of public calls to reduce carbon emissions and protect the planet

A 27-year-old Queensland surrogate conceived naturally with her husband shortly after another couple’s embryo was implanted; the babies were delivered together by C-section, forcing a court to untangle an unprecedented parentage case

Long before fluid sexuality and gender expression entered the mainstream, Curry’s Frank-N-Furter gave generations of queer fans a model of fearless desire, flamboyance and self-expression, turning ‘Rocky Horror’ into a lasting cultural refuge

Two women needed emergency brain surgery after riding the Six Flags coaster days apart; both families say the park later offered them food, including McDonald’s, as serious questions mounted over years of reported injuries

The Canadian actor voiced Optimus Prime across films, TV and games for decades, played Eeyore in ‘Winnie the Pooh’ and created the Predator’s signature clicking sound